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SERTRALINE DRUG INFORMATION, ABOUT SERTRALINE

WHAT IS SERTRALINE?

Sertraline (generic Zoloft®) is used to treat panic attacks, depression, obsessive compulsive disorders (OCD), and post-traumatic stress disorder (PTSD). Sertraline works to help restore balance to certain natural chemicals in the brain.

Sertraline is also used to treat a severe form of premenstrual syndrome (premenstrual dysphoric disorder- PMDD) in women and premature ejaculation in men.

HOW TO USE

Take sertraline tablets by mouth, usually once a day. May be taken with or without food (or as directed by your doctor).

It is best to take your dose at the same time every day. Take it either in the morning or in the evening.

Your dosage will vary depending on your medical condition and your response to therapy.

It is important to continue taking sertraline even if you feel better.

It may take up to 4 weeks before the full benefits of sertraline take effect.

Do not stop taking sertraline without consulting with your doctor.

SERTRALINE SIDE EFFECTS

If any of these sertraline side effects continue or get worse, notify your doctor.

• dizziness
• diarrhea
• dry mouth
• drowsiness
• headache
• trouble sleeping
• nausea, upset stomach

Tell your doctor immediately if any of these serious sertraline side affects occur:

• appetite loss
• decreased interest in sex
• increased sweating/flushing
• mental/mood changes - unusual or severe
• tremor - uncontrolled movements
• unusual fatigue
• unusual weight loss

Tell your doctor immediately if any of these unlikely but serious sertraline side effects occur:

• changes in sexual ability
• painful and/or prolonged erection
• vision changes

Tell your doctor immediately if any of these highly unlikely but very serious sertraline side effects occur:

• chest pain
• irregular heartbeat
• fainting
• muscle pain
• seizures
• tinnitus (ringing in the ears)
• trouble swallowing

An allergic reaction to sertraline is not likely. However, seek immediate medical attention if it occurs. Symptoms of an allergic reaction are:

• trouble breathing
• severe dizziness
• itching
• rash
• swelling

If you notice other side effects not listed here, contact your doctor.

PRECAUTIONS

Tell your doctor your medical history, especially:

• any allergies
• seizures
• heart problems
• kidney disease
• liver problems

Sertraline may make you drowsy or dizzy. Use caution if mental alertness is needed, such as, while driving or using machinery.

Limit your consumption of alcoholic beverages.

The elderly may be more sensitive to the effects of sertraline. Use caution.

SERTRALINE and PREGNANCY

During pregnancy, sertraline should be used only when clearly needed. Discuss the benefits and risks with your medical provider.

SERTRALINE and BREAST FEEDING

Sertraline will pass into breast milk. Because of the potential risk to the infant, breastfeeding while using this drug is not recommended. Consult your doctor before breastfeeding.

SERTRALINE DRUG INTERACTIONS

Serious, or fatal, drug interactions with certain other medications may occur.
For 2 weeks before or after taking sertraline, avoid taking MAO inhibitors, for example:

• linezolid
• moclobemide
• furazolidone
• isocarboxazid
• phenelzine
• selegiline
• procarbazine
• tranylcypromine

Ask your doctor or pharmacist for more information.

Sertraline is not recommended for use with:

• astemizole
• weight loss drugs, for example
  • sibutramine
  • phentermine
• terfenadine

Ask your doctor or pharmacist for more information.

Tell your doctor of all the medication you use, prescription and over-the-counter, especially:

• nefazodone
• other SSRI antidepressants, for example:
  • citalopram
  • fluoxetine
    
    
• "triptan" migraine drugs, for example
  • zolmitriptan
  • sumatriptan
    
    
• venlafaxine
• tramadol
• tricyclic antidepressants, for example:
  • amitriptyline
  • nortriptyline
    
    
• clozapine
• cimetidine
• flecainide
• lithium
• any herbal/natural products, for example
  • ayahuasca
  • melatonin
  • St. John's wort
    
    
• blood thinners, for example
  • warfarin
    
    
• propafenone
• tryptophan
• trazodone

Tell your doctor if you use drugs that could cause you to become drowsy, for example:

• certain antihistamines (e.g., diphenhydramine)
• anti-anxiety drugs (e.g., diazepam)
• anti-seizure drugs (e.g., carbamazepine)
• tranquilizers
• sleep medicine
• sedatives
• narcotic pain relievers (e.g., codeine)
• psychiatric medicines (e.g., phenothiazines such as chlorpromazine)
• muscle relaxants

Tell your doctor if you take drugs which affect the heart rhythm (QTc prolongation), for example:

• procainamide
• dofetilide
• pimozide
• quinidine
• sotalol
• sparfloxacin
• diuretics, for example:
  • furosemide
  • hydrochlorothiazide

Ask your doctor or pharmacist for more information.

Do not start or stop taking sertraline without your doctor's or pharmacist's approval.

SERTRALINE OVERDOSE

If an overdose of sertraline is suspected, contact your local poison control center (1-800-222-1222) or emergency room (911) immediately. Symptoms of overdose may include:

• lightheadedness
• fainting
• severe dizziness
• irregular heartbeat

NOTES

Do not share sertraline or any medication with others.

Your doctor may order laboratory and/or medical tests monitor your progress.

MISSED DOSE

If you miss a dose of sertraline, take it as soon as you remember. However, if it is almost time for the next dose, skip your missed dose. Resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE

Store sertraline at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Avoid light and moisture. Do not store it in the bathroom.

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